Grant Recipients
2019 - 2020
STUART TANGYE, PhD
Garvan Institute of Medical Research, AUSTRALIA
STAT3-mediated regulation of the human immune response - unraveling the complexities of disease pathogenesis of Job's syndrome
ELLEN RENNER, MD
Helmholtz Zentrum München, GERMANY
Fighting Staphylococcus aureus infections at the mucosal surface in Job Syndrome
PETER OLBRICH, MD, PhD
OLAF NETH, MD, PhD
Hospital Infantil Universitario Virgen del Rocio, SPAIN
JAK-inhibition to prevent the development of pulmonary complications in autosomal dominant Hyper IgE Syndrome
BERTRAND BOISSON, PhD
The Rockefeller University, USA
Dissecting the mechanism of STAT3 dominance underlying Job's Syndrome
2020 - 2021
HONGMEI MOU, PhD
Massachusetts General Hospital / Harvard Medical School, USA
Impaired Epithelial Differentiation and Host Defense as a Mechanism for Pulmonary Complications in Job Syndrome Patients
ANDREW GENNERY, MD
ALEXANDRA FREEMAN, AUSTEN WORTH, RAFFAELE BADOLATO
University of Newcastle Upon Tyne, UK
Investigating Health Status and Quality of Life in Patients with Autosomal Dominant Hyper IgE Syndrome
VERA P. KRYMSKAYA, PhD, MBA, FCPP
ANDREW PARIS, MD
University of Pennsylvania, USA
Nanotechnology as a novel cellular therapy for patients with Job Syndrome
SCOTT SNAPPER, MD, PhD
Boston Children's Hospital, USA
Investigating a Non-Transcriptional Role for IL-10-STAT3 in Mitochondrial Metabolism and AD-HIES
2021 - 2022
TONI CATHOMEN, PhD
BODO GRIMBACHER, MD
University of Freiburg, GERMANY
Treating Hyper-IgE-Syndrome by genome editing in CD34+ hematopoietic stem and progenitor cells
MARK GORELIK, MD
Columbia University Vagelos School of Medicine, US
The role of fibroblast specific STAT3 expression in pneumatocele development and gastrointestinal perforation in AD-HIES
2022 - 2023
BEATE HAGLE
CAROLA VOSS (co-principal)
Helmholtz Zentrum Munchen, GERMANY
Evaluation of alveolar function, regeneration and gene repair in Job Syndrome
SUK SEE DE RAVIN, MD, PhD
Laboratory of Clinical Immunology and Microbiology, NIAID, USA
Next-generation CRISPR Base Editing Approaches to Treat Job Syndrome
2023 - 2024
MARIA A. CUROTTO DE LAFAILLE, PhD
Associate Professor, Icahn School of Medicine at Mount Sinai
Cross-regulation of STAT signaling pathways in lung pathology of experimental HIES
STUART TANGYE, PhD
Senior Principal Research Fellow, Lab Head, Garvan Institute of Medical Research
Immune dysregulation in Job Syndrome - elucidating mechanisms of STAT3-mediated host defense, humoral immunity and immune-mediated lung pathology
2024
DR. RASMUS O. BAK
Aarhus University, Denmark
Next generation CRISPR/Cas-based ex vivo Gene Editing of Autologous Hematopoietic Stem Cells as a Curative Treatment of Job Syndrome