Job Syndrome can be treated with a number of medications, including antibiotic prophylaxis.

Treatment for infections should begin promptly. Since patients with Job Syndrome suffer from significant eczema and skin infections that subsequently lead to deep-seated infections from pathogens, skin care and the prompt treatment of such infections is crucial to the efficient management of the disease. Topical moisturizing creams and the use of topical steroids can provide an effective healing mechanism for severe bouts of eczema. In addition, anti-septic treatments such as dilute bleach baths can greatly reduce the bacterial burden to the skin and avoid an occurrence of the far more serious antibiotic-resistant bacteria. Skin abscesses may require incision, and drainage, but can largely be prevented with the use of prophylactic oral antibiotics.

While the role of prophylactic antibiotics has not been rigorously researched, there is agreement within the medical community that the use of antibiotics against Staphylococcus aureus in the treatment of Job Syndrome can be successful.

Surgery in the lung should only be performed when necessary as there has been a high rate of complications. Following treatment of acute cases of pneumonia, pulmonary cysts or cavities have been known to encourage colonization with Pseudomonas aeruginosa, Aspergillus and other fungal species. These superinfections can be a difficult aspect of the Job Syndrome treatment.

Potential management strategies include continuous treatment with antifungal drugs and/or aerosolized antibiotics. Candidiasis in Job Syndrome patients rarely spreads to deeper tissues, and such infections respond well to oral antifungals. While the over-use of antibiotics, and antifungals, is discouraged when treating patients who don’t have immune diseases, the under-use of such a treatment in Job Syndrome patients leaves this group at risk for infections that are debilitating, and dangerous. Job Syndrome patients who do have an infection may frequently feel and appear well. As a result, doctors who are unfamiliar with Job Syndrome have difficulty spotting the true signs of infection. 

Job Syndrome patients are candidates for immunoglobulin replacement therapy. Bone marrow transplantation is considered for more severe Job Syndrome cases especially for those individuals who suffer from lung disease caused by recurrent infections to their lungs due to the condition.