News

Job Research Foundation Announces First-Ever Grant Offer

– Up to $500,000 in Grants Available to Researchers Investigating Causes/Treatments of Rare Multisystem Immunodeficiency Disorder –

(NEW YORK CITY, NY, JUNE 27, 2018) – The Job Research Foundation, which seeks to help find a cure for Job Syndrome by providing the scientific community with additional opportunities to further research into the rare multisystem immunodeficiency disorder, has announced that they are offering up to $500,000 in grants for the first time. The grant funding will be awarded to scientific researchers who are interested in investigating the causes of, and treatments for, Job Syndrome.

“Our long-term goal is to help advance research to find a cure for Job Syndrome,” said Ted Lavin, co-founder of The Job Research Foundation. “In the short term, we hope the research will improve the treatments for patients suffering from Job Syndrome. These grants are meant to make both goals a reality as soon as possible.”

The Job Research Foundation will award a pair of two-year grants of up to $200,000 each, and a pair of two-year grants of up to $50,000 each to qualified grantees in December of 2018. Special consideration will be given to research focused on Job Syndrome and Pulmonary Function. It is anticipated that these grants will be available on an annual basis for new applicants. Previous applicants can apply in subsequent years to extend their research. The application process is open to researchers world-wide from July 1st through November 15th, 2018 and grants will be awarded by December 17th, 2018.

Job Syndrome, also known as Autosomal Dominant Hyperimmunoglobulin E Syndrome (AD-HIES), was discovered in 1966 and is a multisystem immunodeficiency disorder found in males and females worldwide. It can be inherited from either parent or result from a new genetic mutation, a mutation of the STAT3 gene, which is encoded on chromosome 17q21.

Only about 300 cases of Job’s Syndrome have been reported since it was first discovered. Patients often suffer from life-threatening complications from basic infections as the disease makes the immune system extremely sensitive to bacteria. People with the syndrome often have multiple, recurring ailments, such as skin infections that cause lesions and boils, and lung infections that cause pneumonia. The disease was named after the Biblical character Job who suffered from boils.

Visit https://www.jobresearchfoundation.org/ for additional details about The Job Syndrome Foundation and for information about the Grant Application Process.


Skin infections turned out to be sign of serious problem for little girl

The Washington Post

By Sandra G. Boodman July 28

The pediatrician was blunt but not unkind. Even so, her unequivocal message made Jan Wiese bristle.

“You know, this is really not normal,” the Northern Virginia doctor said as she examined 2-year-old Lucy Wiese for the first time. Struck by the little girl’s medical history, especially her repeated skin infections, the doctor recommended that Lucy see a pediatric immunologist in Baltimore.

“I was kind of offended,” Wiese recalled of the encounter. It had not occurred to her or her physician husband that their daughter’s infections might signal something more serious than a toddler’s normal — if acute — reaction to unfamiliar germs.

Years later, Wiese ruefully recalled how indignant she felt. “Of course she was right,” Wiese conceded. Read More...